Novel Oxooxepane Derivatives and New Phorbic Acid Derivative from Paederia scandens

摘要

Paederia scandens (Lour.) Merrill (Rubiaceae) is a climbing plant that is widely distributed in China, India, Japan, Korea, the Philippines, the USA, and Vietnam. All parts of this plant have been used traditionally for the treatment of rheumatic arthritis, jaundice, dysentery, and dyspepsia and as an emetic and diuretic. In previous studies, iridoid glycosides have been isolated and characterized as major secondary metabolites of P. scandens. Their extracts and individual constituents have been reported to exhibit various biological activities, including mti-Helicobacter pylori, antinociceptive, and antitumor promoting activities, as well as xanthine oxidase inhibition and uricosuric effect. The present study describes the isolation of two new 7-oxooxe-pane derivatives having a naturally unprecedented skeleton and a new phorbic acid analog from the aerial parts of P. scandens.