Towards a durable RNAi gene therapy for HIV-AIDS.

摘要

BACKGROUND: RNA interference (RNAi) can be employed as a potent antiviral mechanism. OBJECTIVE: To discuss RNAi approaches to target pathogenic human viruses causing acute or chronic infections, in particular RNAi gene therapy against HIV-1. METHODS: A review of relevant literature. RESULTS/CONCLUSIONS: The future of antiviral RNAi therapeutics is very promising. RNAi was discovered only a decade ago, and although we are still in the early days, the first clinical trials are already ongoing.