An efficient route to quinolines and other compounds by iron-catalysed cross-dehydrogenative coupling reactions of glycine derivatives

摘要

A simple method has been developed for functionalizing glycine derivatives by iron-catalysed cross-dehydrogenative coupling (CDC) reactions. In particular, N-arylglycine derivatives reacted with alkynes by oxidative C-H/C-H coupling reactions to provide a series of substituted quinolines starting from commercially inexpensive materials. Moreover, N-arylglycine esters can be oxidatively coupled to ketones by using FeCl _3 in the presence of DDQ.