Synthesis of (4R,12S,15S,16S,19R,20R,34S)-Muricatetrocin and (4R,12S,15S,16S,19R,20R,34S)-Muricatertrocin,Two Potent Inhibitors of Mitochondrial Complex I

摘要

(4R,12S,15S,16S,19R,20R,34S)-Muricatetrocin (1) and (4R,12S,15S,16S,19R,20R,34S)-muricatetrocin (2) were synthesized by a modular synthetic strategy. Both compounds act as potent inhibitors of mitochondrial complex I. Compound 1 showed analtical data in a greement with howiicin E and a fit with the date for muricatetrocin A if one reassigns the reported ~(13)C signals for C(13) and C(14). Compound 2 matched muricatetrocin B in respect to all NMR data. However,a lower optical rotation was found for 2 ([#alpha#]_D~(28)=+6.7) than was reprted for the natural product ([#alpha#]_D~(25)=+15.0).