Synthesis and Absolute Configuration of Nocardione A and B, Furano-o-naphthoquinone-Type Metabolites of Nocardia sp. with Antifungal, Cytotoxic, and Enzyme Inhibitory Activities

摘要

(±)-Nocardione A (1), (S)-(-)-nocardione A, and (R)-(+)-nocardione B (2) were synthesized by starting from the enantiomers of propylene oxide and 5-benzyloxy (or methoxy)-1-tertralone. The absolute configurations of the naturally occurring (-)-1 and (-)-2 were established as (S).