Highly enantioselective henry reaction catalyzed by C_2-symmetric modular BINOL-oxazoline Schiff base copper(II) complexes generated in situ

摘要

A 16-member library of C_2-symmetric modular chiral BINOL-oxazoline Schiff base copper(II) complex catalysts generated in situ was easily generated in a one-pot, three-component manner. This approach avoided the need for isolation and characterization of ligands and greatly improved the catalyst screening efficiency. This modular catalyst library was evaluated in the asymmetric Henry reaction, for which good yields (up to 98%) and good to excellent enantioselectivities (up to 98% ee) were obtained under mild conditions. A new modular library of C_2-symmetric chiral BINOL-oxazoline Schiff base copper(II) complex catalysts was generated in situ in a one-pot, three-component manner. This library greatly improves catalystscreening efficiency and was used in the asymmetric Henry reaction, for which good yields and good to excellent enantioselectivities were obtained under mild conditions.