Expanding the scope of the direct regiospecific asymmetric aldol reaction to enones and dienones catalyzed by a BINOL-derived br?nsted acid

摘要

Chiral phosphoric acid (R)-1a has been shown to be an efficient Br?nsted acid catalyst for the useful asymmetric synthesis of various acyclic and endo-and exocyclic β-hydroxyenones through a regiospecific aldol reaction between α,β-unsaturated ketones and ethyl glyoxalate. Moreover, two unprecedented examples involving sensitive dienones are reported.