Efficient synthesis of substituted 3-iodofurans by electrophilic cyclization of propargylic oxirane derivatives

摘要

The electrophilic cyclization of various propargylic oxirane compounds and 12 offers an efficient and straightforward route to highly substituted iodofurans under mild reaction conditions. Further functionalization has demonstrated that the iodo derivatives obtained are potential synthetic intermediates for the amplification of molecular complexity.