Any role for endoscopy screening or surveillance for esophageal adenocarcinoma among persons with GERD?

摘要

After the strong and dose-dependent association between gastroesophageal reflux symptoms and risk of esophageal adenocarcinoma was established,1 the potential benefit of screening or surveillance endoscopy strategies gained increased interest. Yet, although a strong relative risk among reflux symptoms, obesity, male sex, older age, and this cancer was identified, no clinical recommendations for increased endoscopy were made because the incidence of esophageal adenocarcinoma was too low and the number of persons needed to follow up was unfeasibly high, at least in Sweden. The 5-year survival rate of less than 15% of patients with an invasive esophageal adenocarcinoma3 has, however, prompted an intensified research of potential benefits of endoscopic screening and surveillance to make early cancer detection possible (ie, in a stage at which such cancers could be curable).