In vivo confocal microscopy of congenital aniridia-Associated keratopathy

摘要

PurposeTo explore the in vivo morphological changes of cornea and limbus in aniridia-Associated keratopathy (AAK).MethodsThree cases of AAK were examined with the application of in vivo confocal microscopy (IVCM).ResultsAbnormal structure of wing and basal layer of epithelium, the loss of subbasal nerves, and the presence of goblet cells at central cornea could be identified in the most severe case, along with the absence of Vogt palisades. The less extent of abnormalities in corneal epithelial cells, subbasal nerve, and Vogt palisades were visible in the moderate or mild cases.ConclusionsThe morphological changes of cornea and limbus vary in AAK, and IVCM is a promising tool to determine the degree of limbal stem cell deficiency in patients with AAK.