Mass-spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: comparison to IHC and FISH

Catenacci Daniel V. T.; Liao Wei-Li; Zhao Lei; Whitcomb Emma; Henderson Les; ODay Emily; Xu Peng; Thyparambil Sheeno; Krizman David; Bengali Kathleen; Uzzell Jamar; Darfler Marlene; Cecchi Fabiola; Blackler Adele; Bang Yung-Jue; Hart John; Xiao Shu-Yuan; Lee Sang Mee; Burrows Jon; Hembrough Todd

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Mass-spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: comparison to IHC and FISH

机译：基于质谱的胃食管肿瘤组织中Her2的定量：与IHC和FISH的比较

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Trastuzumab has shown a survival benefit in cases of Her2-positive gastroesophageal cancer (GEC). Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) currently determine eligibility for trastuzumab-based therapy. However, these low-throughput assays often produce discordant or equivocal results.

机译：曲妥珠单抗在Her2阳性胃食管癌（GEC）病例中显示出生存获益。免疫组织化学（IHC）和荧光原位杂交（FISH）当前确定了基于曲妥珠单抗的治疗的资格。但是，这些低通量分析通常会产生不一致或模棱两可的结果。

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《Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association》 |2016年第4期|共14页
作者
Catenacci Daniel V. T.; Liao Wei-Li; Zhao Lei; Whitcomb Emma; Henderson Les; ODay Emily; Xu Peng; Thyparambil Sheeno; Krizman David; Bengali Kathleen; Uzzell Jamar; Darfler Marlene; Cecchi Fabiola; Blackler Adele; Bang Yung-Jue; Hart John; Xiao Shu-Yuan; Lee Sang Mee; Burrows Jon; Hembrough Todd;
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正文语种 eng
中图分类肿瘤学;
关键词
Her2 expression; HER2 (ERBB2) amplification; Gastric; Esophageal; Gastroesophageal adenocarcinoma; Stomach cancer; SRM-MS; Selected reaction monitoring mass spectrometry; Companion diagnostic; Clinical biomarker assay; Multiplex protein expression analysis in FFPE tissue;

机译：Her2表达;HER2（ERBB2）扩增;胃癌;食管癌;胃食管腺癌;胃癌;SRM-MS;选择反应监测质谱;伴侣诊断;临床生物标志物检测;FFPE组织中多重蛋白表达分析;

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专利

1. Mass-spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: comparison to IHC and FISH [J] . Catenacci Daniel V. T., Liao Wei-Li, Zhao Lei, Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association . 2016,第4期

机译：基于质谱的胃食管肿瘤组织中Her2的定量：与IHC和FISH的比较
2. Methods for evaluating HER2 status in breast cancer: comparison of IHC, FISH, and real-time PCR analysis of formalin-fixed paraffin-embedded tissue [J] . Hans Olsson, Agneta Jansson, Birgitta Holmlund, Pathology and Laboratory Medicine International . 2013,第4期

机译：评估乳腺癌中HER2状态的方法：IHC，FISH的比较以及福尔马林固定石蜡包埋的组织的实时PCR分析
3. An Immunohistochemical and Fluorescence In Situ Hybridization-based Comparison Between the Oracle HER2 Bond Immunohistochemical System, Dako HercepTest, and Vysis PathVysion HER2 FISH Using Both Commercially Validated and Modified ASCO/CAP and United Kingdom HER2 IHC Scoring Guidelines [J] . Anthony OGrady, David Allen, Lisa Happerfield, Applied immunohistochemistry and molecular morphology: AIMM . 2010,第6期

机译：Oracle HER2键免疫组织化学系统，Dako HercepTest和Vysis PathVysion HER2 FISH的基于免疫组织化学和荧光原位杂交的比较，均使用商业验证和修改的ASCO / CAP和英国HER2 IHC评分指南
4. Quantitation of MET using Mass Spectrometry for Clinical Application: Correlation with IHC and MET Gene Amplification in FFPE Tumor Tissue [C] . Todd Hembrough, Wei-Li Liao, Sheeno Thyparambil, International Mass Spectrometry Conference . 2014

机译：用质谱法定量临床应用：与IHC的相关性，并在FFPE肿瘤组织中得到基因扩增
5. HER2Delta16: a tumor-specific oncogene that drives tumorigenesis and trastuzumab resistance in HER2+ breast cancer. [D] . Huynh, Felicia C. 2015

机译：HER2Delta16：一种肿瘤特异性癌基因，可驱动HER2 +乳腺癌的肿瘤发生和曲妥珠单抗。
6. Mass spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: Comparison to IHC and FISH [O] . Daniel V.T. Catenacci, Wei-Li Liao, Lei Zhao, -1

机译：基于质谱的胃食管肿瘤组织中Her2的定量：与IHC和FISH的比较
7. Mass spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: Comparison to IHC and FISH [O] . Daniel Catenacci, Wei-Li Liao, Lei Zhao, 2015

机译：胃食管肿瘤组织中MER2的质谱法定量：与IHC和FISH的比较

Mass-spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: comparison to IHC and FISH

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