Subacute toxicity of sodium salinomycin in the anticoccidial preparation Synvertas plv. ad us. vet. in chickens

摘要

The study presents information about the toxic action of sodium salinomycin in the anticoccidial preparation Synvertas, plv. ad us. vet. (Biotika, Slovenska Lupca, Slovak Republic), in chickens under the conditions of subacute intoxication. The experiment was carried out in chickens of the meat hybrid Ross of both sexes, 5 weeks old. The first experimental group of chickens (n=10) was administered sodium salinomycin at a dose of 5.3 mg/kg b.w. (53 mg of the preparation) which corresponded to 1/20 of LD_(50). The second experimental group (n=10) was treated with sodium salinomycin at a dose of 10.6 mg/kg b.w. (106 mg of the preparation), i.e. 1/10 of LD_(50). The preparation was administered once daily by a tube into a crop in the form of water suspension (1:5), at early hours for 7 d. The control group consisting of 6 chickens received the same volume of water in the same way as the experimental chickens. During the experiment, the chickens were fed mixed feed Hyd-03 ad libitum and had unlimitedaccess to drinking water. We observed the overall health state of chickens and looked for possible clinical symptoms of intoxication, determined live body weight, haematological parameters (number of erythrocytes and leukocytes, leukogram, haemoglobin content and haematocrit value), biochemical parameters in blood serum (activity of aspartate aminotransferase, alanine aminotransferase and alkaline aminotransferase, total proteins, urea, bilirubin, cholesterol, calcium and phosphorus) and the presence of patho-morphological changes. The dose of 5.3 mg sodium salinomycin per kg b.w. in the respective preparation was tolerated well when administered for 7 d. and had no toxic effects on chickens. It did not influence adversely their health, weight gains, haematological and biochemical parameters and caused no patho-morphological changes. Sodium salinomycin at a dose of 10.6 mg/kg b.w. resulted in toxic effects manifested in growth depression, significantly increased content of urea and cholesterol and sporadic small intestine petechia. Clinical symptoms of intoxication were not observed. Our investigations point to good tolerance of the tested preparation Synvertas despite the fact that it was administered in relatively high doses.