Efficacy of Cabazitaxel in Castration-resistant Prostate Cancer Is Independent of the Presence of AR-V7 in Circulating Tumor Cells

Onstenk Wendy; Sieuwerts Anieta M.; Kraan Jaco; Van Mai; Nieuweboer Annemieke J. M.; Mathijssen Ron H. J.; Hamberg Paul; Meulenbeld Hielke J.; De Laere Bram; Dirix Luc Y.; van Soest Robert J.; Lolkema Martijn P.; Martens John W. M.; van Weerden Wytske M.; Jenster Guido W.; Foekens John A.; de Wit Ronald; Sleijfer Stefan

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Efficacy of Cabazitaxel in Castration-resistant Prostate Cancer Is Independent of the Presence of AR-V7 in Circulating Tumor Cells

机译：卡巴他赛在去势抵抗性前列腺癌中的功效与循环肿瘤细胞中AR-V7的存在无关

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Background: Androgen receptor splice variant 7 (AR-V7) in circulating tumor cells (CTCs) from patients with metastatic castration-resistant prostate cancer (mCRPC) was recently demonstrated to be associated with resistance to abiraterone and enzalutamide. Cabazitaxel might, however, remain effective in AR-V7-positive patients.

机译：背景：最近已证明，来自转移性去势抵抗性前列腺癌（mCRPC）患者的循环肿瘤细胞（CTC）中的雄激素受体剪接变体7（AR-V7）与对阿比特龙和enzalutamide的耐药有关。然而，卡巴他赛在AR-V7阳性患者中可能仍然有效。

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《European urology》 |2015年第6期|共7页
作者
Onstenk Wendy; Sieuwerts Anieta M.; Kraan Jaco; Van Mai; Nieuweboer Annemieke J. M.; Mathijssen Ron H. J.; Hamberg Paul; Meulenbeld Hielke J.; De Laere Bram; Dirix Luc Y.; van Soest Robert J.; Lolkema Martijn P.; Martens John W. M.; van Weerden Wytske M.; Jenster Guido W.; Foekens John A.; de Wit Ronald; Sleijfer Stefan;
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正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
AR-V7; Androgen receptor; Cabazitaxel; Castration-resistant prostate cancer; CellSearch; Circulating tumor cells; Metastatic prostate cancer;

机译：AR-V7;雄激素受体;卡巴他赛;抗结直肠耐药性;细胞搜索;循环肿瘤细胞;转移性前列腺癌;
入库时间 2022-08-18 10:59:33

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1. Efficacy of Cabazitaxel in Castration-resistant Prostate Cancer Is Independent of the Presence of AR-V7 in Circulating Tumor Cells [J] . Onstenk Wendy, Sieuwerts Anieta M., Kraan Jaco, European urology . 2015,第6期

机译：卡巴他赛在去势抵抗性前列腺癌中的功效与循环肿瘤细胞中AR-V7的存在无关
2. Efficacy of Cabazitaxel in Castration-resistant Prostate Cancer Is Independent of the Presence of AR-V7 in Circulating Tumor Cells [J] . Onstenk Wendy, Sieuwerts Anieta M., Kraan Jaco, European urology . 2015,第6期

机译：卡巴他赛在去势抵抗性前列腺癌中的功效与循环肿瘤细胞中AR-V7的存在无关
3. Efficacy of Cabazitaxel in Castration-resistant Prostate Cancer Is Independent of the Presence of AR-V7 in Circulating Tumor Cells [J] . Onstenk Wendy, Sieuwerts Anieta M., Kraan Jaco, European urology . 2015,第6期

机译：Cabazitaxel在抗阉割前列腺癌中的疗效与循环肿瘤细胞中的AR-V7的存在无关
4. Application of an antibody-independent, highly sensitive PRISM-SRM proteomics approach for monitoring TMPRSS2-ERG fusion proteins in prostate cancer cell lines and tumor tissues [C] . Jintang He, Xuefei Sun, Tujin Shi, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：抗体无抗体，高敏感棱镜-SRM蛋白质组学方法在前列腺癌细胞系和肿瘤组织中监测TMPRSS2-ERG融合蛋白的应用
5. Mechanism of Extracellular Matrix Induced Tumor Survival and Drug Resistance in Castration-Resistant Prostate Cancer [D] . Chaudhary, Pooja. 2019

机译：细胞外基质诱导肿瘤存活和抗阉割前列腺癌的耐药机制
6. Role of Circulating Tumor Cells (CTC) Androgen Receptor Full Length (AR-FL) and Androgen Receptor Splice Variant 7 (AR-V7) in a Prospective Cohort of Castration-Resistant Metastatic Prostate Cancer Patients [O] . Carlo Cattrini, Alessandra Rubagotti, Linda Zinoli, 2019

机译：循环肿瘤细胞（CTC）雄激素受体全长（AR-FL）和雄激素受体剪接变体7（AR-V7）在去势抵抗性转移性前列腺癌患者的预期队列中的作用
7. Melatonin Inhibits Androgen Receptor Splice Variant-7 (AR-V7)-Induced Nuclear Factor-Kappa B (NF-κB) Activation and NF-κB Activator-Induced AR-V7 Expression in Prostate Cancer Cells: Potential Implications for the Use of Melatonin in Castration-Resistant Prostate Cancer (CRPC) Therapy [O] . Vincent Wing Sun Liu, Wing Lung Yau, Chun Wai Tam, 2017

机译：褪黑激素抑制雄激素受体剪接变体-7（aR-V7）诱导的核因子-κB（NF-κB）激活和NF-κB激动剂诱导的前列腺癌细胞中aR-V7的表达：使用褪黑激素的潜在影响去势抵抗性前列腺癌（CRpC）治疗
8. Single Cell Characterization of Prostate Cancer-Circulating Tumor Cells. [R] . J. D. Brooks 2013

机译：前列腺癌循环肿瘤细胞的单细胞表征。

Efficacy of Cabazitaxel in Castration-resistant Prostate Cancer Is Independent of the Presence of AR-V7 in Circulating Tumor Cells

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