Eight-Year Follow-Up of an Initial Case with NF-kB Decoy Oligodeoxynu-cleotide Transfection After Coronary Stent Implantation

摘要

Background: Nuclear factor-kappa B (NF-kB) plays a pivotal role in vascular remodeling after percutaneous coronary intervention (PCI) with a stent implantation.Methods and Results: This is the first clinical report to demonstrate the effect of NF-kB decoy oligodeoxynucleotide (ODN) on the prevention of restenosis after an eight-year observation period. We revealed that decoy ODN treatment suppressed neointimal formation in comparison to that without ODN transfected stent lesion in the same artery.Conclusion: We showed the long-term usefulness of NF-kB decoy ODN transfer after PCI. ^g>CT, coronary intervention, gene therapy, nuclear factor-kappa B, oligodeoxynucleotide, restenosis, stents.