Synthesis and antibacterial activity of 1beta-methyl-2-(5-(N-substituted-2-hydroxy iminoethyl)pyrrolidin-3-ylthio)carbapenem derivatives.

摘要

The synthesis of a new series of 1-methylcarbapenems having the substituted thiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. In particular, compounds 12b and 12k showed the most potent antibacterial activity.