Synthesis and antitumor activity of new shikonin glycosides.

Su Y; Xie J; Wang Y; Hu X; Lin X

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Synthesis and antitumor activity of new shikonin glycosides.

机译：新的紫草素苷的合成及其抗肿瘤活性。

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Eleven shikonin glycosides were synthesized and evaluated for their antitumor activity in vitro. Some of them were found to exhibit cytotoxic activities against both drug sensitive cell lines (K562, MCF-7 and HL60) and their drug resistant cell sublines (K562/ADR, MCF-7/ADR and HL60/ADR).

机译：合成了十一种紫草素苷，并在体外评估了它们的抗肿瘤活性。发现其中一些对药物敏感性细胞系（K562，MCF-7和HL60）及其耐药细胞亚系（K562 / ADR，MCF-7 / ADR和HL60 / ADR）均显示出细胞毒活性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第7期|共6页
作者
Su Y; Xie J; Wang Y; Hu X; Lin X;
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正文语种 eng
中图分类医药、卫生;劳动卫生;
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1. Synthesis and antitumor activity of new shikonin glycosides. [J] . Su Y, Xie J, Wang Y, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第7期

机译：新的紫草素苷的合成及其抗肿瘤活性。
2. Shikonin exerts antitumor activity in Burkitt’s lymphoma by inhibiting C-MYC and PI3K/AKT/mTOR pathway and acts synergistically with doxorubicin [J] . Fan Ni, Xianbo Huang, Zhenzhen Chen, Scientific reports. . 2018,第1期

机译：Shikonin通过抑制C-Myc和Pi3k / Akt / mtor途径，在Burkitt的淋巴瘤中发挥抗肿瘤活性，并用多柔比星协同作用
3. The evaluation of potent antitumor activities of shikonin coumarin-carboxylic acid, PMMB232 through HIF-1 alpha-mediated apoptosis [J] . Han Hong-Wei, Zheng Chao-Sai, Chu Shu-Juan, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2018,第期

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4. A New Class of Radiation-Activating Antitumor Prodrugs Releasing 5-Fluorodeoxyuridine: Synthesis, Reactivity and Biological Activity [C] . S.Sakakibara, L.Zhou, M.Mori, Japan-China bilateral symposium on radiation chemistry . 2000

机译：一种新的辐射活化抗肿瘤前药，释放5-氟脱氧尿苷：合成，反应性和生物活性
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机译：糖基氟化物的制备和反应：I.寡糖的合成：六糖的合成和总的合成。二。合成2-脱氧糖苷的新方法。
6. Shikonin Derivatives from Onsoma visianii Decrease Expression of Phosphorylated STAT3 in Leukemia Cells and Exert Antitumor Activity [O] . Zeljko Todorovic, Jelena Milovanovic, Dragana Arsenijevic, 2021

机译：来自Onsoma Visianii的Shikonin衍生物降低白血病细胞中磷酸化Stat3的表达并施加抗肿瘤活性
7. Antitumor activity of shikonin, alkannin and their derivatives. II. X-ray analysis of cyclo-alkannin leucoacetate, tautomerism of alkannin and cyclo-alkannin and antitumor activity of alkannin derivatives. [O] . USHIO SANKAWA, HIDEAKI OTSUKA, YOSHITOMO KATAOKA, 1981

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Synthesis and antitumor activity of new shikonin glycosides.

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