Oral Lactobacillus paracasei improves skin barrier function recovery and reduces local skin inflammation.

摘要

Recently, the incidence of subjects presenting dry skin and eczema has considerably increased in industrialized countries [1]. Dry skin is characterized by marked sensitivity of skin to physical (heat, cold...) or chemical (topical product application) stimuli and is often associated with an impairment of skin barrier function recovery. Nutritional approaches are postulated to be effective in improving skin health. Series of preclinical and clinical data provide evidence that specific probiotics, such as Lactobacillus paracasei CNCM1-2116 (ST11), could trigger the immune system and/or down-regulate immune-related disorders [2-3]. We demonstrated recently that ST11 inhibited substance P-induced skin inflammation and accelerated skin barrier function recovery in vitro [4]. To confirm the effect of ST11 on skiii barrier function and skin inflammation, two preclinical studies were conducted (figure 1A and B).