Phytochemical and biological investigation of Stevia rebaudiana Bertoni; 1-labdane-type diterpene.

摘要

Five labdane diterpenoids (austroinulin, iso-austroinulin, sterebin E, sterebin E acetate and sterebin A acetate), together with hydrocarbons, aliphatic alcohols, beta-amyrin, beta-sitosterol and stigmasterol were isolated from the chloroform-soluble fraction of the methanol extract of Stevia rebaudiana leaves. Chlorogenic and caffeic acids were isolated from the ethyl acetate fraction. All the isolated compounds were identified using spectral tools. The chloroform and methanol extracts demonstrated significant anti-inflammatory activity and caused marked inhibition of carrageenan-induced paw oedema in rats.