Membranous glomerulonephritis associated with autoimmune hepatitis and primary biliary cirrhosis overlap syndrome: a very rare condition.

摘要

Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBG) are typical autoimmune liver diseases that mainly affect middle-aged women. However, these disorders are not just limited to the liver and are often associated with various extrahepatic manifestations or other autoimmune diseases [ 1 ]. The term hepatic overlap syndrome is used to describe the coexistence of two autoimmune hepatic diseases, whereas AIH/PBG overlap syndrome is the most common form, affecting almost 10% of patients with AIH or PBG [2], Although the coexistence of AIH or PBG has been reported separately with a variety of other autoimmune diseases, there are limited reports of such association in a case of AIH/PBG overlap. Herein, we describe a case of AIH/PBG overlap associated with membranous glomerulonephritis (MGN), whose kidney and liver pathologies resolved after treatment of prednisolone, azathiopyr-ine (AZT) and ursodeoxycholic acid (UDCA).