Improving scalability and comparability by using single-use bioreactors for large-scale manufacturing

摘要

Although single-use bioreactors are widely accepted for R&D and seed train applications, their use in real production environments has stayed very limited until now. However, with the recent introduction of single-use bioreactors with a classical design this is now changing. These new bioreactors reduce the need for additional optimisation when moving away from stainless steel and simplify the upscaling process. Therefore it is expected that these single-use bioreactors will more and more find their way into large-scale production applications, allowing for total single-use solutions throughout the complete process.