CGRP receptor blockade by MK-8825 alleviates allodynia in infraorbital nerve-ligated rats

Michot B.; Kayser V.; Hamon M.; Bourgoin S.

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CGRP receptor blockade by MK-8825 alleviates allodynia in infraorbital nerve-ligated rats

机译：MK-8825阻断CGRP受体可减轻眶下神经结扎大鼠的异常性疼痛

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BackgroundPrevious data showed that, in rats, anti-migraine drugs (triptans, olcegepant) significantly reduced mechanical allodynia induced by infraorbital nerve (ION) ligation but not that evoked by sciatic nerve (SN) ligation. Whether this also occurs with MK-8825, a novel anti-migraine drug also acting through CGRP receptor blockade (but chemically unrelated to olcegepant) was tested in the present study, which also investigated possible anti-neuroinflammatory effects of this drug.

机译：背景先前的数据显示，在大鼠中，抗偏头痛药物（曲普坦，奥格西汀）显着降低了眶下神经（ION）结扎引起的机械性异常性疼痛，但坐骨神经（SN）结扎并没有引起机械性异常性疼痛。在本研究中，我们还测试了MK-8825是否也发生这种情况，MK-8825是一种新的抗偏头痛药物，它也通过CGRP受体阻滞起作用（但化学上与Olcegepant无关），还研究了该药物可能的抗神经炎作用。

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《European journal of pain :》 |2015年第2期|共10页
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Michot B.; Kayser V.; Hamon M.; Bourgoin S.;
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1. CGRP receptor blockade by MK-8825 alleviates allodynia in infraorbital nerve-ligated rats [J] . Michot B., Kayser V., Hamon M., European journal of pain : . 2015,第2期

机译：MK-8825阻断CGRP受体可减轻眶下神经结扎大鼠的异常性疼痛
2. Differential effects of calcitonin gene-related peptide receptor blockade by olcegepant on mechanical allodynia induced by ligation of the infraorbital nerve vs the sciatic nerve in the rat [J] . MichotB., BourgoinS., ViguierF., Pain. . 2012,第9期

机译：olcegepant阻断降钙素基因相关肽受体对大鼠眶下神经与坐骨神经结扎所致机械性异常性疼痛的差异作用
3. MK-8825: A potent and selective CGRP receptor antagonist with good oral activity in rats [J] . BellI.M., StumpC.A., GallicchioS.N., Bioorganic and Medicinal Chemistry Letters . 2012,第12期

机译：MK-8825：一种有效且选择性的CGRP受体拮抗剂，在大鼠中具有良好的口服活性
4. Role of CGRP Receptors in Cerebral Blood Flow Increase Upon Trigeminovascular Activation in Rats: An Implication of CGRP Mechanism of Migraine Attacks [C] . N. Suzuki, M. Fukuda, S. Tsukahara, International Pain Clinic . 2004

机译：CGRP受体在大鼠的三峡血管活化时脑血流量的作用：偏头痛攻击CGRP机制的含义
5. A Peptide Comprising the Src-Interacting Domain of NADH Dehydrogenase Subunit 2 Alleviates Complete Freund's Adjuvant-Induced Allodynia in Rats. [D] . Barszczyk, Andrew. 2010

机译：包含NADH脱氢酶亚基2 Src相互作用域的肽减轻大鼠完全弗氏佐剂诱导的异常性疼痛。
6. Optogenetic stimulation of the motor cortex alleviates neuropathic pain in rats of infraorbital nerve injury with/without CGRP knock-down [O] . Jaisan Islam, Elina KC, Byeong Ho Oh, 2020

机译：电动机皮质的致敏刺激减轻了眶下神经损伤大鼠的神经性疼痛或者没有CGRP击倒
7. Chronic Blockade of Melanocortin Receptors Alleviates Allodynia in Rats with Neuropathic Pain [O] . Michael J. Cousins, Dorien H. Vrinten, Roger A. H. Adan, 2013

机译：黑色素皮质激素受体的慢性阻滞减轻神经性疼痛大鼠的异常性疼痛。

CGRP receptor blockade by MK-8825 alleviates allodynia in infraorbital nerve-ligated rats

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