where values R-R5, X are given in p. 1 of the invention claim. Compounds are antagonists of tachykinin receptors and show the efficiency for treatment of patients with inflammatory sicknesses, pains or migraine and asthma. Also, some of these substances are agents blocking calcium channel and they can be benefit for treatment of patients with cardiovascular disorders, for example, angina, hypertensia and ischemia. Invention describes a pharmaceutical composition based on compounds of the formula (I) and a method of blockade of neurokinin-1 receptors in mammals also. EFFECT: improved method of receptor blocking, valuable curative properties. 9 cl, 7 dwg, 67 ex"/>
SUBSTITUTED HETEROCYCLES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALT, PHARMACEUTICAL COMPOSITION FOR BLOCKADE OF NEUROKININ-1 RECEPTORS IN MAMMALS, METHOD OF BLOCKADE OF NEUROKININ-1 RECEPTORS IN MAMMALS
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SUBSTITUTED HETEROCYCLES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALT, PHARMACEUTICAL COMPOSITION FOR BLOCKADE OF NEUROKININ-1 RECEPTORS IN MAMMALS, METHOD OF BLOCKADE OF NEUROKININ-1 RECEPTORS IN MAMMALS
SUBSTITUTED HETEROCYCLES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALT, PHARMACEUTICAL COMPOSITION FOR BLOCKADE OF NEUROKININ-1 RECEPTORS IN MAMMALS, METHOD OF BLOCKADE OF NEUROKININ-1 RECEPTORS IN MAMMALS
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new substituted heterocycles of the general formula (I) where values R-R5, X are given in p. 1 of the invention claim. Compounds are antagonists of tachykinin receptors and show the efficiency for treatment of patients with inflammatory sicknesses, pains or migraine and asthma. Also, some of these substances are agents blocking calcium channel and they can be benefit for treatment of patients with cardiovascular disorders, for example, angina, hypertensia and ischemia. Invention describes a pharmaceutical composition based on compounds of the formula (I) and a method of blockade of neurokinin-1 receptors in mammals also. EFFECT: improved method of receptor blocking, valuable curative properties. 9 cl, 7 dwg, 67 ex
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机译：领域：有机化学，药学。物质：本发明描述了通式（I）的新的取代的杂环<图像文件=“ 00000002.GIF” he =“ 28” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 22” />其中值RR 5 ，X在p中给出。本发明的权利要求1。该化合物是速激肽受体的拮抗剂，对炎症性疾病，疼痛或偏头痛和哮喘患者具有治疗效果。而且，这些物质中的一些是阻断钙通道的物质，它们可有益于治疗患有心血管疾病例如心绞痛，高血压和局部缺血的患者。本发明描述了基于式（I）化合物的药物组合物，以及在哺乳动物中也阻断神经激肽-1受体的方法。效果：改进的受体阻断方法，有价值的疗效。 9 cl，7 dwg，67 ex
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