Rocuronium for rapid sequence induction in morbidly obese patients: a prospective study for evaluation of intubation conditions after administration 1.2 mg kg(1) ideal body weight of rocuronium.

摘要

Rocuronium is considered as non-deporalising muscle relaxant that can be used instead of succinylcholine for rapid sequence induction (RSI). The dose (l.2 mgkg"1) provides neuromuscular blockade that allows for atraumatic intubation within 60-90 s. In morbidly obese patients, RSI or fast intubation is still considered the preferred method of induction to general anaesthesia, except for expected difficult airways in which fibre optic intubation is better.1 The pharmacology of rocuronium was studied in several trials to estimate the adequate dosing in morbidly obese patients: per kilogram of ideal body weight (IBW), corrected body weight (CBW) or total body mass. It is suggested that rocuronium can be dosed basing on IBW However, these studies were testing the typical induction dose of rocuronium -0.6 mgkg"1, but in the case of RSI, higher doses are used (l.2 mgkg).