Myelopeptide-5 abolishes virus-induced immunosuppression by restoring T cell functions

摘要

Myelopeptide-5 (MP-5; synthetic analog of endogenous low-molecular-weight peptide Val-Val-Tyr-Pro-Asp) neutralized the immunosuppressive effects of antiviral vaccines (influenza, measles, and measles/parotitis) and stimulated their immunogenicity by restoring functional activity of T cells, suppressed by the viruses. Specific binding of MP-5 to CD4+ lymphocyte (its target cell) was studied using [3H]MP-5 (dissociation constant 2.03×10-7 M).