Regulation of Body Composition and Bioenergetics by Estrogens

摘要

Evidence points to an important role of estradiol (E-2) in the regulation of body composition and bioenergetics. Basic and preclinical research shows that the disruption of E-2 signaling through either genetic manipulation or surgical intervention accelerates fat accumulation, with a disproportionate increase in abdominal fat. Clinical evidence for the regulation of body composition and bioenergetics by E-2 is less consistent. Evidence exists both for and against menopause as the mediator of changes in body composition. Thus, a need remains to better understand the metabolic actions of estrogens in women and the potential impact on health after the menopause.