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首页> 外文期刊>Bulletin of experimental biology and medicine >Morphology of Synovial Membrane and Articular Cartilage in the Knee Joint in Experimental Chronic Heart Failure
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Morphology of Synovial Membrane and Articular Cartilage in the Knee Joint in Experimental Chronic Heart Failure

机译:实验性慢性心力衰竭膝关节滑膜和关节软骨的形态

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Structural-and-functional reorganization of the synovial membrane and articular cartilage in the knee joint was studied in rats with experimental chronic heart failure. Separation of fibers, decrease in the relative volume density of microcirculatory vessels, and increase in the expression of MMP-9 and caspase 3 were found in the synovial membrane. A decrease in the thickness of the surface layer (tendency to erosion), vacuolization and necrosis of chondrocytes, and increase in their readiness to programmed cell death were observed in the articular cartilage. Changes in the content of type II collagen and metachromasia were revealed in the cartilage matrix. These changes illustrate the development of degenerative arthropathy in cartilage components.
机译:在实验性慢性心力衰竭大鼠中研究了膝关节滑膜和关节软骨的结构和功能重组。在滑膜中发现了纤维的分离,微循环血管的相对体积密度的降低以及MMP-9和caspase 3表达的增加。在关节软骨中观察到了表面层厚度的减少(趋向侵蚀),软骨细胞的空泡化和坏死,以及它们对程序性细胞死亡的准备程度增加。软骨基质中显示II型胶原和变色症含量的变化。这些变化说明了软骨成分退行性关节炎的发展。

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