Maternal consumption of high-fat diet disturbs hypothalamic neuronal function in the offspring: Implications for the genesis of obesity

摘要

Obesity is a consequence of the loss of the coordinated control of caloric intake and energy expenditure. The homeostasis of this system and, thus, the maintenance of body mass stability depends on the activity of hypotha-lamic neurons, which are controlled by hormones, nutrients, environmental temperature, and physical activity, providing signals that play pivotal roles in the modulation of hunger, body temperature, motility, and storage of surplus energy (1).