Statistically Biased Calibration Method for the Real-time Adjustment of Noninvasive Haemoglobin Measurements in a Semi- automated Infusion System

摘要

Closed loop systems are the ultimate solution to ensure that optimal therapies are delivered in a timely manner. A concept of a semi-closed loop infusion system for perioperative semi-automated optimisation of blood pressure and haemodilution is proposed. The key variable for the latter objective is the noninvasively and continuously measured blood haemoglobin concentration. However, it lacks reliability in predicting the haemoglobin in large blood vessels. Our proposed statistically biased calibration method for the adjustment of noninvasively measured Hb enabled better prediction of arterial Hb when it was applied to data from our ongoing clinical trial.