A hybrid approach to gene ranking using gene relation networks derived from literature for the identifi cation of disease gene markers

摘要

For the identifi cation of gene markers involved in diseases, microarray expression profi les have been widely used to prioritize genes. In this paper, we propose a novel approach to gene ranking that employs gene relation network derived from literature along with microarray expression scores to calculate ranking statistics of individual genes. In particular, the gene relation network is constructed from literature by applying syntactic analysis and co-occurrence method in a hybrid manner. For evaluation, the proposed method was tested with publicly available prostate cancer data. The result shows that our method is superior to other existing approaches.