Enantioseparation of aromatic amino acids and amino acid esters by capillary electrophoresis with crown ether and prediction of enantiomer migration orders by a three-dimensional quantitative structure-property relationship/comparative field analysis

摘要

The complete enantioseparations of eight aromatic amino acids and four alkyl esters of 2-phenylglycine were achieved by chiral capillary electrophoresis employing 20 mM Tris-citric acid background electrolyte (pH 2.50) containing 5.0 mM of (+)-18-crown-6-tetracarboxylic acid. The relative migration times (RMTs) to that of 6-aminonicotinic acid were characteristic of each enantiomer with good within-day precisions (% relative standard deviation (RSD)