A comparison of the desensitising efficacy of two commercially available dentifrices with different modes of action was conducted in a randomised, examiner-blind, two-arm, parallel group, 8-week, longitudinal clinical study. Dentifrice A, (Sensodyne Multi Action Iso-Active), contained 50000 ppm KNO3 and 1450 ppm fluoride as NaE. Dentifrice B, Colgate Sensitive Pro-Relief, contained a combination of 80000 ppm arginine, bicarbonate, calcium carbonate, and 1450 ppm fluorine as NaMFP. Subjects (N = 110), stratified into two groups (N = 55), brushed twice-daily for 60 s, over an 8-week period. Sensitivity status, compliance, and safety were determined at 1, 2, 4, and 8 weeks. A fixed-effects ANCOVA statistical model was applied to the Intent-To-Treat population using a two-sided 5% significance level. After 8 weeks, the treatment groups using Dentifrice A and Dentifrice B exhibited mean reductions from baseline of 49% and 45% in air sensitivity visual analogue scale (VAS) score, 61% (both) in examiner-based Schiff Sensitivity score, and clinically significant reductions in tactile pain threshold; all reductions were statistically significant (P < 0.0001). Both treatment groups also exhibited significant reductions across all sensitivity measures at 1, 2, and 4 weeks (P < 0.0059, Dentifrice A; P < 0.0137, Dentifrice B). Dentine hypersensitivity is a common condition variously reported to affect anywhere between 3 and 57% of the population depending on the method of diagnosis, geography, and population chosen. It is characterised by a short sharp pain arising from exposed dentine in response to thermal, evaporative, tactile, osmotic, or chemical stimuli that cannot be ascribed to any other form of dental defect , Although symptoms of the condition are acute and episodic they can persist for years. Without proper clinical management dentine hypersensitivity can have a significant impact on a sufferers quality of life . Human dentine contains large numbers of fluid-filled tubules, typically 1-5 mum in diameter, that run radially from the dentine-pulp junction to the surface of the dentine-enamel or dentine-cementum junction. Tubule lumens, that are unsclerosed, free of debris, and open at the dentine surface, facilitate transmission of the stimulus to the pain receptors present at the pulp/odontoblast interface.
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