VANADIUM BROMOPEROXIDASE-CATALYZED OXIDATION OF THIOCYANATE BY HYDROGEN PEROXIDE

摘要

Vanadium bromoperoxidase isolated from marine algae has been shown to catalyze the oxidation of the pseudohalide thiocyanate by hydrogen peroxide: (1) thiocyanate was found to inhibit bromide peroxidation through preferential oxidation of thiocyanate over bromide; (2) oxidized thiocyanate generated by the V-BrPO/NCS-/H2O2 system oxidizes 5-thio-2-nitrobenzoic acid to 5,5-dithiobis(2-nitrobenzoic acid); (3) V-BrPO catalyzes the thiocyanation of 1,3,5-trimethoxybenzene and 1,2-dimethylindole to 1-thiocyanato2,4,6-trimethoxybenzene and 1,2-dimethyl-3 -thiocyanato-indole, respectively; and (4) the C-13 NMR of the oxidation of (KSCN)-C-13 by H2O2 catalyzed by V-BrPO shows the formation of several oxidized thiocyanate species, including the putative dithiocyanate ether, which is unstable, hypothiocyanate, thiooxime, as well as bicarbonate. [References: 39]