Comment: Gomez-Martin et al. Level of HER2 gene amplification predicts response and overall survival in HER2-positive advanced gastric cancer treated with trastuzumab. J Clin Oncol 2013. (18)

摘要

Summary: In this retrospective study from Spain, 90 patients with metastatic gastric cancer with HER 2 over-expression by immunohistochemistry (IHC), dual color silver in situ hybridization, or fluorescent in situ hybridization (FISH) treated with trastuzumab were included.Gene copy number (GCN) of HER 2 or the HER 2/CEP17 ratio was assessed with dual color silver in situ hybridization or FISH from tumor samples and correlated with outcome. In total, 66 cases were included for analysis.