Protracted febrile myalgia in an afebrile child with familial Mediterranean fever

摘要

Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent self-limited attacks of fever and serositis. It primarily occurs in ethnic groups that reside in the Mediterranean basin, such as Turks, Sephardic Jews, Arabs and Armenians. The gene responsible for FMF, MEFV, encodes a pyrin or marenostrin protein that has a key role in regulation of activity of inflammasomes. Certain mutations, particularly M694V, lead to a more severe course of the disease with high risk of development of amyloidosis.[1]