Risk of cancer in relatives of children born with isolated cleft lip and palate

摘要

TO THE EDITOR:Cancer is a multifactorial disease where both genetic and environmental factors play a significant role. Preventive plans for decreasing cancer incidence include the motivation of healthy behaviors such as avoiding tobacco use, having five to 10 servings of fruits and vegetables per day, having 1 hr of physical activity per day, avoiding being overweight, and using sun protection. The identification of genetic risk factors, both cancer susceptibility gene polymorphisms or mutations, will allow the development of strategies that include the target of more aggressive screening programs and chemo-preventive treatments.