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首页> 外文期刊>International Journal of Pharmaceutics >Cone milling of compacted flakes: Process parameter selection by adopting the minimal fines approach
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Cone milling of compacted flakes: Process parameter selection by adopting the minimal fines approach

机译:压实薄片的圆锥铣削:采用最小细度方法选择工艺参数

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摘要

Cone mill was well studied for milling of wet agglomerates. This study evaluated the effects of various process parameters of cone milling roller compacted flakes on the granules produced. Impeller sidearm shapes, screen surface profiles and impeller speeds were studied. Impeller speed was found to play a major role in determining the granule attributes. Besides this, median size, size distribution and percent fines of a milled granule population were mainly determined by the size reduction mechanisms of different impellers and screens. Pre-breaking followed by shearing and slicing of flakes inside the milling chamber was primarily responsible for determining the size, size distribution and percent fines of milled granules. The pre-breaking action could be achieved using teethed round sidearm impeller and lowered the need for screen-based size reduction, thus generating less fines. The shearing and slicing of flakes due to the raised impaction edges of the grater screen also helped to minimize the production of fines. Therefore, the lowest percentage of fines was observed when the teethed round sidearm impeller was used with a grater screen. The results indicated that fines can be reduced considerably with the judicious selection of a suitable impeller and screen combination in the cone mill.
机译:锥磨机已被广泛研究用于湿附聚物的研磨。这项研究评估了圆锥磨辊压实薄片的各种工艺参数对生产的颗粒的影响。研究了叶轮侧臂的形状,筛面轮廓和叶轮速度。发现叶轮速度在确定颗粒属性中起主要作用。除此之外,中值粒度,粒度分布和粉状颗粒种群的细粉百分比主要由不同叶轮和筛网的粒度减小机制决定。在研磨室内进行预破碎,然后对薄片进行剪切和切片,主要决定了研磨颗粒的尺寸,尺寸分布和细粉百分比。可以使用带齿的圆形侧臂叶轮来实现预破碎动作,并降低了基于筛网尺寸减小的需求,因此产生的罚款更少。由于刨丝筛的凸起的冲击边缘而导致的薄片的剪切和切片也有助于减少细粉的产生。因此,当带齿的圆形侧臂叶轮与刨丝机筛网一起使用时,观察到最低的罚款百分比。结果表明,通过在锥磨机中明智地选择合适的叶轮和筛网组合,可以显着降低粉尘。

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