Trend of lipid ratios associated with well known risk factors of coronary artery disease in different age: a population based study of 31,999 healthy individuals.

摘要

BACKGROUND: Developing current evidence in order to better assess the rates and pattern of the CAD risk factors among populations is pivotal in CAD risk stratification. METHODS: A large scale population based survey involving 31,999 healthy people was designed. Risk factors information was provided from medical history, physical examination and laboratory assessments. RESULTS: Increasing linear trend was observed for: cigarette smoking (CS) (P=0.001), systolic blood pressure (SBP)> 140 mmHg (P=0.001), diastolic blood pressure (DBP)> 90 mmHg (P=0.001), SBP> 120 mmHg (P=0.001), DBP> 80 mmHg (P=0.001), fasting blood glucose (FBS)> 126 Mg/dl (P=0.001), total cholesterol (TC)>200Mg/dl (P=0.001), triglyceride> 200 Mg/dl (P=0.001), TC> 170 Mg/dl (P=0.001), and LDL-c> 130 Mg/dl (P=0.001). Multivariable adjusted magnitudes of associations for risk factors across age groups were statistically different, thus in an age group of 30-40 years: cigarette smoking, high DBP, increased body mass index (BMI), high level of FBS and lower level of education demonstrated strongest associations. In an age group of 40-50 years: CS, high level of DBP, increased BMI, FBS> 126 Mg/dl, and SBP> 120 mmHg, in an age group of 50-60 years: SBP> 120 mmHg, CS, higher level of DBP, and FBS> 126 Mg/dl, and in above 60 years: SBP> 120 mmHg, HDL-c< 45 Mg/dl, C/S and FBS have demonstrated the strongest associations. CONCLUSIONS: Trends of increment in the mean levels of SBP, DBP, TC, LDL-c and FBS are statistically significant across age decades. Multivariate strength of associations for CAD risk factors demonstrates significant differences across age groups.