Relationship between umbilical artery Doppler waveform analysis and perinatal prognosis in women with intrahepatic cholestasis of pregnancy.

摘要

Intrahepatic cholestasis of pregnancy (ICP), characterized by generalized pruritusrelevation in serum bile acids, and abnormal liver function tests, occurs primarily during the second half of pregnancy and disappears a few days after delivery [1]. ICP is associated with adverse obstetric outcomes, including preterm delivery, fetal distress, and sudden intrauterine fetal death [1,2]. The role of fetal monitoring in predicting fetal well-being among patients with ICP remains controversial since fetal death may still occur within 24 hours of a normal cardiotocograph, a few days or hours after normal antepartum testing, or even during fetal heart rate tracing [3-5]. Reducing the occurrence of fetal death depends on active management, which may lead to high rates of iatrogenic preterm delivery and low birth weight.