Signaling from novel splice variants of hormone receptors in cancer.

摘要

A number of splice variants of hormone receptors have recently been described in malignant neoplasms. Signaling by these novel receptor isoforms differ from their wild type counterparts, raising interesting questions as to possible roles in the initiation, progression, and metastatic potential of various tumors. This review summarizes recent findings on the signaling of novel variants of hormone receptors, including human HER-2eu, the secretin receptor, the CCK-B/gastrin receptor and fibroblast growth factor receptor-2.