Bone marrow harvest versus peripheral stem cell collection for haematopoietic stem cell donation in healthy donors.

摘要

Nurses play a significant role in preparing healthy donors in pre- and post-haematopoietic stem cell donation procedures. Therefore, it is vital for the nurses to educate and pre-empt the donor for the potential adverse effects and provide assurance in relation to their experience.Six trials with 807 donors were included in the review. All trials were part of larger randomised controlled trials of bone marrow and peripheral blood stem cell allogenic transplants. No significant differences were noted in the age or gender of donors, with all donors being related to the recipient. The methodological quality of the studies was poor because of attrition bias and failure of long-term follow up. Adequate allocation concealment was evident in one trial. Blinding of the assessor of outcomes and the donors was not possible in this setting.