Effect on absorption and oxidative stress of different oral Coenzyme Q_10 dosages and intake strategy in healthy men

摘要

The effect of various dosages and dose strategies of oral coenzyme Q_10 (Q_10) administration on serum Q10 concentration and bioequivalence of various formulations are not fully known. Subjects and Methods: In a randomized, double blind, placebo controlled trial 60 healthy men, aged 18-55 years, were supplemented with various dosages and dose strategies of coenzyme Q_10 soft oil capsules (Myoqinon 100 mg, Pharma Nord, Denmark) or crystalline 100 mg Q10 powder capsules or placebo. After 20 days blood levels were compared and oxidative load parameters, malondialdehyde (MDA) and thiobarbituric acid reactive substances (TBARS) were monitored to evaluate bioequivalence. All the subjects were advised to take the capsules with meals. Blood samples were collected after 12 hours of overnight fasting at baseline and after 20 days of Q_10 administration. Compliance was evaluated by counting the number of capsules returned by the subjects after the trial.