Thrombocytopenia following high-dose chemotherapy with carboplatin, etoposide and thiotepa in patients with testicular germ cell cancer

摘要

Thrombocytopenia is one of the major dose-limiting toxicities in chemotherapeutic regimens containing carboplatin. In a clinical study 17 patients received high-dose chemotherapy with carboplatin, etoposide and thio-tepa (GET), subsequent autologous stem cell rescue as well as additional administration of thrombocyte concentrates. The objective of the present work was to perform pharmaco-kinetic/pharmacodynamic (PK/PD) modeling to characterize the time-course of thrombocytopenia in this therapy regimen and the contribution of each chemotherapeutic agent to the observed hematological toxicity.