LETTERS TO THE EDITOR

摘要

Some time ago a. paper entitled "Center specificity in the limited sampling model (LSM): can the LSM developed from healthy subjects be extended to disease states?" was published in this journal [Mahmood 2003]. In this article, the LSM method to estimate the area under the curve (AUC) from a limited number (1 - 3) of blood samples was evaluated, with a focus on the accuracy and precision of the predicted AUC in patients with hepatic or renal impairment, using LSM developed fromhealthy subjects. The evaluation was based on both simulated data and clinical data, a valuable and sound approach to evaluate LSM. However, after carefully reading the article, and after correspondence with the author Dr. I. Mahmood, I have several comments on this paper#