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Transanal electroresection of small rectal cancerA sole treatment?

机译:经肛门电切除术治疗小直肠癌的唯一治疗和探索;

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PURPOSE:Because abdominoperineal resection is associated with high morbidity and mortality, there is interest in local treatment of distal rectal carcinoma. Our technique of transanal electroresection ensures full‐thickness tumor excision and complete histopathologic examination.METHODS:From July 1983 to July 1990, 227 patients underwent surgery. Criteria for cure were no extramural invasion (61 exclusions) and negative margins (34 exclusions). Six patients underwent postoperative radiotherapy and, therefore, were excluded.RESULTS:Among those included were 126 patients (66 men), who had a mean age of 68±11 (median, 68) years. Median tumor size was 35 mm. Distance from anal verge was less than 6 cm for 68 percent and 6‐10 cm for 30 percent of patients. Deepest layer invaded was as follows: submucosa (T1), 35 percent; inner muscular layer (T2a), 42 percent; outer muscular layer (T2b), 23 percent. There was one postoperative death. Immediate postoperative course was uneventful for 94 percent of patients; at long‐term, five cases of incontinence and two stenoses were noted (6 patients). Median follow‐up was 88 (1‐137) months. Global survival was 71 and 46 percent, and cancer‐specific survival was 85 and 81 percent at 5 and 10 years, respectively. Of 35 patients (28 percent) with recurrence, 24 were treated. Global survival after recurrence was 72 and 50 percent at one and two years, respectively. The only pejorative prognostic factors isolated for survival or recurrence were mucinous contingent and intratumoral vascular invasion.CONCLUSION:Results of local treatment for rectal carcinoma in selected patients are favorable (5‐year specific survival, 85 percent). Decisive prognostic factors are seldom isolated, but some patients would benefit from an adjuvant therapy.
机译:由于腹会阴切除术与高发病率和死亡率相关,因此对远端直肠癌的局部治疗很感兴趣。我们的经肛门电切术技术确保了全层肿瘤切除和完整的组织病理学检查。方法&结肠;1983 年 7 月至 1990 年 7 月,227 例患者接受了手术。治愈标准是无壁外侵袭(61排除)和阴性边缘(34排除)。6例患者接受了术后放疗,因此被排除在外。结果&结肠;纳入的患者中有126例(66名男性),平均年龄为68±11(中位数,68)岁)。中位肿瘤大小为 35 mm。68%的患者与肛门边缘的距离小于6厘米,30%的患者与肛门边缘的距离为6&连字符;10厘米。最深的浸润层如下:结肠粘膜下层(T1),35%;内肌层(T2a),42%;外肌层(T2b),23%。术后死亡1例。94%的患者术后即刻病程平安无事,5例尿失禁和2例狭窄,6例患者。中位随访&连字符&连字符;为88(1&连字符;137)月。5年和10年时,全球生存率分别为71%和46%,癌症特异性生存率分别为85%和81%。在35例复发患者中,24例接受了治疗。1年和2年复发后全球生存率分别为72%和50%。唯一分离出的生存或复发的贬义预后因素是粘液性或条件和瘤内血管浸润。结论&结肠;局部治疗直肠癌患者结果良好(5&连字符;年特异性生存率,85%)。决定性的预后因素很少被孤立,但一些患者会从辅助治疗中获益。

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