Effect of oral administration of freeze-dried Lactobacillus acidophilus on small bowel bacterial overgrowth in patients with end stage kidney disease: reducing uremic toxins and improving nutrition

摘要

A study showed that 2 strains of L, acidophilus (LA, NCFM and BG2F04) can lower the toxin, dimethylamine (DMA), and the carcinogen nitrosodimethylamine (NDMA), in the blood and improve nutrition. In 19 dialysis patients, treatment with twice daily oral doses of 109 c.f.u. LA/80-mg capsule resulted in a significant decrease in blood DMA from 282±91 to 163±82μg/100 ml. In a subgroup of 7 patients, blood NDMA decreased by an average of 46% from 236±69 to 118±38 ng/kg blood. In 6 of the 19 patients, 2nutritional parameters (body weight and energy intake) increased (from 49.8±3.8 to 51.4±3.8 kg and from 27.9±3.7 to 32.4±8.2 kcal/kg respectively). It is concluded that there may be a positive role for LA for patients on dialysis with end-stage kidney failure.