Importance of screening for renal disease among the human immunodeficiency virus-infected patient population

摘要

Assessment of tenofovir disoproxil fumarate (TDF)-related nephrotoxidty has become the single commonest reason for the referral of human immunodeficiency virus (HIV)-infected patients to renal specialists in many centres.1 Although there is concern about the renal effects of TDF, they are seen in only a minority of patients (1-2%). However, these adverse effects are important as they may be profound, particularly the Fanconi syndrome.2 TDF has added importance to the screening and management of renal disease amongst the HIV-infected population, which is at particular risk of kidney disease. In fact, despite the use of antiretrovirals, the prevalence of kidney disease among the HIV-infected cohort has increased.