A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase II alpha

摘要

A novel complex, [Cu(acetylethTSC)Cl]Cl center dot 0.25C(2)H(5)OH 1 (where acetylethTSC = (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. In vitro studies showed that complex 1 acted as a poison inhibitor of human topoisomerase II alpha, which may account for the observed anti-cancer effects. (C) 2015 Elsevier B.V. All rights reserved.