Successful Long-Term Treatment with Linezolid for Disseminated Infection with Multiresistant Nocardia farcinica

摘要

Nocardiosis is a common infection in organ transplant recipients and other immunosuppressed patients, caused by different Nocardia species. Nocardia farcinica is one of the most predominant Nocardia species isolated in these patients, frequently presenting resistance to multiple antibiotics used as first-line agents [1, 2]. Linezolid is an oxazolidinone agent apparently well designed for treating chronic osteomyelitis, but data on its effectiveness and tolerability in patients on prolonged therapy with linezolid are limited.The authors present the case of an immunosuppressed patient who developed disseminated nocardiosis caused by a multiresistant N. farcinica strain requiring long-term treatment with linezolid.