Synthesis of some 2-substituted amino 3(N-p-tolyl carboxamido)-4,5-trimethylene thiophenes as potent 193 NSAIDs

摘要

A series of 2-(omicron-substituted acetamido)-4,5-trimethylene thiophene 4a-c have been synthesized by replacing omicron-chloro of 3 by various nucleophiles.Schiff's bases and 2-acetyl derivatives of 2-amino-3-(N-p-tolyl carboxamido)-4,5-trimcthylene thiophene 1 were also synthesized.The synthesized compounds have been characterized on the basis of elemental analysis and spectral studies and screened for their analgesic and antiinflammatory activities.Some of the compounds exhibit significant activities.