Microwave Induced Synthesis and Biological Evaluation of Some Schiff Bases of 2-Amino-3-(N-Chlorophenyl Carboxamido)-4,5-dimethyl Thiophenes

摘要

The new series of 2-amino-3-(N-chlorophenyl carboxamido)-4,5-dimethyl thiophenes (I-III) were synthesized by Gewald reaction.Later,the compounds I-III were subjected to treatment with ten different substituted arylaldehydes to yield thirty new Schiff bases (Ia-j to IIIa-j).All the compounds were characterized by spectral data.Antimicrobial activity has been performed using cup diffusion method for all the synthesized compounds.The compounds Ia,IIa and IIIa with 2-chlorophenyl substituent and Ib,IIb and IIIb with 4-chlorophenyl substituent at X exhibited significant antibacterial activity against S.aureus,B.subtilis and E.coli comparable to ampicillin.